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504466 LY-404,039 - CAS 635318-55-7 - Calbiochem

504466
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Key Specifications Table

Empirical FormulaCAS #
C₇H₉NO₆S 635318-55-7

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      Description
      OverviewA highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149 nM and 92 nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88 nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia.
      Catalogue Number504466
      Brand Family Calbiochem®
      Synonyms(1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
      References
      ReferencesSeeman, P., 2013. Neuropharmacology. 66, 87.
      Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther. 321, 308.
      Fell, M., et al. 2008. J. Pharmacol. Exp. Ther. 326, 209.
      Rodd, Z., et al. 2006. Behav. Brain Res. 171, 207.
      Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs. 11, 833.
      Product Information
      CAS number635318-55-7
      FormWhite powder
      Hill FormulaC₇H₉NO₆S
      Chemical formulaC₇H₉NO₆S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₂ & mGlu₃
      Primary Target K<sub>i</sub>149 nM and 92 nM for human mGlu₂ and mGlu₃, respectively.
      Purity≥98% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      LY-404,039 - CAS 635318-55-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Seeman, P., 2013. Neuropharmacology. 66, 87.
      Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther. 321, 308.
      Fell, M., et al. 2008. J. Pharmacol. Exp. Ther. 326, 209.
      Rodd, Z., et al. 2006. Behav. Brain Res. 171, 207.
      Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs. 11, 833.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      Synonyms(1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
      DescriptionA highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149 nM and 92 nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88 nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia.
      FormWhite powder
      CAS number635318-55-7
      Chemical formulaC₇H₉NO₆S
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (0.25 mg/ml) or dilute NaOH (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.
      Toxicity Standard Handling
      ReferencesSeeman, P., 2013. Neuropharmacology. 66, 87.
      Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther. 321, 308.
      Fell, M., et al. 2008. J. Pharmacol. Exp. Ther. 326, 209.
      Rodd, Z., et al. 2006. Behav. Brain Res. 171, 207.
      Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs. 11, 833.