508150 LY 344864 Hydrochloride - CAS 186544-26-3 - Calbiochem

508150
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Key Specifications Table

Empirical FormulaCAS #
C₂₁H₂₂FN₃O·HCl 186544-26-3

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      Glass bottle 10 mg
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      Description
      OverviewA selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935 (Cat. No. 508014)
      Catalogue Number508150
      Brand Family Calbiochem®
      Synonyms5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
      References
      ReferencesAmrutkar, D. V. et al. 2012. Pain. 153, 830.
      Phebus, L. A. et al. 1997. Life Sci. 61, 2117.
      Product Information
      CAS number186544-26-3
      FormWhite solid
      Hill FormulaC₂₁H₂₂FN₃O·HCl
      Chemical formulaC₂₁H₂₂FN₃O·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT1F
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      LY 344864 Hydrochloride - CAS 186544-26-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Amrutkar, D. V. et al. 2012. Pain. 153, 830.
      Phebus, L. A. et al. 1997. Life Sci. 61, 2117.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      Synonyms5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
      DescriptionA selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935 (Cat. No. 508014)
      FormWhite solid
      CAS number186544-26-3
      Chemical formulaC₂₁H₂₂FN₃O·HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM) or H₂O (10 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAmrutkar, D. V. et al. 2012. Pain. 153, 830.
      Phebus, L. A. et al. 1997. Life Sci. 61, 2117.