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108396 L-Tryptophan


Replacement Information

Key Specifications Table

CAS #EC NumberHill FormulaMolar MassGrade Value
73-22-3200-795-6C₁₁H₁₂N₂O₂204.23 g/molPh Eur,BP,JP,USP

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      Catalogue Number108396
      Product Information
      CAS number73-22-3
      EC number200-795-6
      GradePh Eur,BP,JP,USP
      Hill FormulaC₁₁H₁₂N₂O₂
      Molar Mass204.23 g/mol
      HS Code2933 99 80
      Structure formula ImageStructure formula Image
      Quality LevelMQ500
      Biological Information
      Physicochemical Information
      Melting Point290 °C (decomposition)
      pH value5.5 - 7 (1 g/l, H₂O, 25 °C)
      Bulk density400 kg/m3
      Solubility10 g/l
      Materials Information
      Toxicological Information
      LD 50 oralLD50 Rat 16000 mg/kg
      Safety Information according to GHS
      Storage class10 - 13 Other liquids and solids
      WGKWGK 1 slightly hazardous to water
      Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      StorageStore at +5°C to +30°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Assay (perchloric acid titration, calculated on dried substance)98.5 - 101.0 %
      Identity (IR-spectrum)passes test
      Identity (specific rotation)passes test
      Appearancewhite to almost white, crystalline or amorphous powder
      Appearance of solution (10 g/l, Hydrochloric acid 1 mol/l)clear and not more intense in color than reference solution BY₆
      Appearance of solution (20 g/l, hydrochloric acid 2 mol/l)clear
      pH (10 g/l, CO₂-free water)5.5 - 6.4
      Spec. rotation (α 20/D, 10 g/l, water, calc. on dried substance)-30.0 to -33.0
      Spec. rotation (α 25/D, 10 g/l, water, calc. on dried substance)-29.4 to -32.8
      Spec. rotation (α 20/D, 10 g/l, water, previously dried substance)-30.0 to -33.0
      Chloride (Cl)≤ 200 ppm
      Sulfate (SO₄)≤ 200 ppm
      Heavy metals (as Pb)≤ 20 ppm
      Fe (Iron)≤ 20 ppm
      As (Arsenic)≤ 2 ppm
      Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)≤ 0.2 %
      Ninhydrin-positive substances (LC) (ammonium (570 nm))≤ 0.02 %
      Ninhydrin-positive substances (LC) (total impurities)≤ 0.5 %
      Related substances (HPLC)passes test
      Impurity A ((1,1‘-ethylidenebistryptophan) Peak-E) (acc. to Ph Eur)≤ 10 ppm
      Sum of impurities with RT < tryptophan-peak (acc. to Ph Eur)≤ 100 ppm
      Sum of impurities with RT > tryptophan-peak and up to1,8 times the RT ofacetyltryptophan (acc. to Ph Eur)≤ 300 ppm
      Impurity A ((1,1‘-ethylidenebistryptophan) Peak-E) (acc. to USP)≤ 10 ppm
      Sum of impurities with RT < tryptophan-peak (acc. to USP)≤ 100 ppm
      Sum of impurities with RT > tryptophan-peak, without tryptophan-peak andpeak of „Related Compound B“ (N-acetyltryptophan) (acc. to USP)≤ 300 ppm
      Related substances (TLC)passes test
      Residual solvents (ICH (Q3C))excluded by manufacturing process
      Sulfated ash (600 °C)≤ 0.1 %
      Loss on drying (105 °C; 3 h)≤ 0.30 %
      Bacterial endotoxins≤ 10 I.U./g
      Microbiological test (total aerobic microbial count (TAMC))≤ 100 CFU/g
      Microbiological test (total yeast and mould count (TYMC))≤ 100 CFU/g
      Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
      Corresponds to Ph. Eur., BP, JP, USP.


      Material Qualification Dossier

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      Quality Management Dossier


      Operational Excellence Dossier


      L-Tryptophan SDS


      Safety Data Sheet (SDS) 

      L-Tryptophan Certificates of Analysis

      Product Number PackagingSpecificationLot Number
      1.08396.1000 Plastic bottlePDF Specification Document