504481 L-701,324 - CAS 142326-59-8 - Calbiochem

L-701,324 - CAS 142326-59-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone

Primary Target: NMDA receptors
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₁₄CINO₃ 142326-59-8

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.04481.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA highly potent and selective antagonist for the NMDA receptor glycine site (IC50 = 2.0 nM; Kd = 28 nM; ED50 = 0.9 nM either intraperitoneal (ip) or oral (po) adminited). The first such compounds with significant activity in the central nervous system following oral dosing and a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents.
          Catalogue Number504481
          Brand Family Calbiochem®
          Synonyms7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
          References
          ReferencesPriestley, X., et al. 1996. Neuropharmacology 35, 1573.
          Kulagowski, J., et al. 1994. J. Med. Chem. 37, 1402.
          Bristow, L., et al. 1996. J. Pharmacol. Exp. Ther. 277, 578.
          Obrenovitch, T., et al. 1996. Br. J. Pharmacol. 117, 931.
          Obrenovitch, T., et al. 2012. Bri. J. Pharmacol. 117, 931.
          Product Information
          CAS number142326-59-8
          FormWhite powder
          Hill FormulaC₂₁H₁₄CINO₃
          Chemical formulaC₂₁H₁₄CINO₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNMDA receptors
          Primary Target IC<sub>50</sub>2.0 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          L-701,324 - CAS 142326-59-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Priestley, X., et al. 1996. Neuropharmacology 35, 1573.
          Kulagowski, J., et al. 1994. J. Med. Chem. 37, 1402.
          Bristow, L., et al. 1996. J. Pharmacol. Exp. Ther. 277, 578.
          Obrenovitch, T., et al. 1996. Br. J. Pharmacol. 117, 931.
          Obrenovitch, T., et al. 2012. Bri. J. Pharmacol. 117, 931.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          Synonyms7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
          DescriptionA highly potent and selective antagonist for the NMDA receptor glycine site (IC50 = 2.0 nM; Kd = 28 nM; ED50 = 0.9 nM either intraperitoneal (ip) or oral (po) adminited). The first such compounds with significant activity in the central nervous system following oral dosing and a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents.
          FormWhite powder
          CAS number142326-59-8
          Chemical formulaC₂₁H₁₄CINO₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (36 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPriestley, X., et al. 1996. Neuropharmacology 35, 1573.
          Kulagowski, J., et al. 1994. J. Med. Chem. 37, 1402.
          Bristow, L., et al. 1996. J. Pharmacol. Exp. Ther. 277, 578.
          Obrenovitch, T., et al. 1996. Br. J. Pharmacol. 117, 931.
          Obrenovitch, T., et al. 2012. Bri. J. Pharmacol. 117, 931.