504481 L-701,324 - CAS 142326-59-8 - Calbiochem

504481
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Key Specifications Table

Empirical FormulaCAS #
C₂₁H₁₄CINO₃ 142326-59-8

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      Glass bottle 10 mg
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      Description
      OverviewA highly potent and selective antagonist for the NMDA receptor glycine site (IC50 = 2.0 nM; Kd = 28 nM; ED50 = 0.9 nM either intraperitoneal (ip) or oral (po) adminited). The first such compounds with significant activity in the central nervous system following oral dosing and a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents.
      Catalogue Number504481
      Brand Family Calbiochem®
      Synonyms7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
      References
      ReferencesPriestley, X., et al. 1996. Neuropharmacology 35, 1573.
      Kulagowski, J., et al. 1994. J. Med. Chem. 37, 1402.
      Bristow, L., et al. 1996. J. Pharmacol. Exp. Ther. 277, 578.
      Obrenovitch, T., et al. 1996. Br. J. Pharmacol. 117, 931.
      Obrenovitch, T., et al. 2012. Bri. J. Pharmacol. 117, 931.
      Product Information
      CAS number142326-59-8
      FormWhite powder
      Hill FormulaC₂₁H₁₄CINO₃
      Chemical formulaC₂₁H₁₄CINO₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>2.0 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      L-701,324 - CAS 142326-59-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Priestley, X., et al. 1996. Neuropharmacology 35, 1573.
      Kulagowski, J., et al. 1994. J. Med. Chem. 37, 1402.
      Bristow, L., et al. 1996. J. Pharmacol. Exp. Ther. 277, 578.
      Obrenovitch, T., et al. 1996. Br. J. Pharmacol. 117, 931.
      Obrenovitch, T., et al. 2012. Bri. J. Pharmacol. 117, 931.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      Synonyms7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
      DescriptionA highly potent and selective antagonist for the NMDA receptor glycine site (IC50 = 2.0 nM; Kd = 28 nM; ED50 = 0.9 nM either intraperitoneal (ip) or oral (po) adminited). The first such compounds with significant activity in the central nervous system following oral dosing and a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents.
      FormWhite powder
      CAS number142326-59-8
      Chemical formulaC₂₁H₁₄CINO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (36 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPriestley, X., et al. 1996. Neuropharmacology 35, 1573.
      Kulagowski, J., et al. 1994. J. Med. Chem. 37, 1402.
      Bristow, L., et al. 1996. J. Pharmacol. Exp. Ther. 277, 578.
      Obrenovitch, T., et al. 1996. Br. J. Pharmacol. 117, 931.
      Obrenovitch, T., et al. 2012. Bri. J. Pharmacol. 117, 931.