422682 Kir1.1 Inhibitor, VU591 - Calbiochem

422682
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₆H₁₂N₆O₅

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422682-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, Kir1.1 (IC50 = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over Kir6.2. In addition, it exhibits a modest off-target effect on the GABAA receptor (IC50 = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.
      Catalogue Number422682
      Brand Family Calbiochem®
      SynonymsInward rectifier potassium channel Kir1.1 blocker, VU591
      References
      ReferencesBhave, G., et al. 2011. Mol Pharmacol. 79, 42.
      Product Information
      FormLight gray solid
      Hill FormulaC₁₆H₁₂N₆O₅
      Chemical formulaC₁₆H₁₂N₆O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Kir1.1 Inhibitor, VU591 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Kir1.1 Inhibitor, VU591 - Calbiochem Certificates of Analysis

      TitleLot Number
      422682

      References

      Reference overview
      Bhave, G., et al. 2011. Mol Pharmacol. 79, 42.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-May-2012 JSW
      SynonymsInward rectifier potassium channel Kir1.1 blocker, VU591
      DescriptionA cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, Kir1.1 (IC50 = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over Kir6.2. In addition, it exhibits a modest off-target effect on the GABAA receptor (IC50 = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.
      FormLight gray solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆H₁₂N₆O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml; clear, dark brown solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesBhave, G., et al. 2011. Mol Pharmacol. 79, 42.