Product Information
Applications
ApplicationKN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.
Biological Information
Primary Targetcam kinase 2
Primary Target K<sub>i</sub>370 nM against rat brain CaM kinase II
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

KN-93 - CAS 139298-40-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

KN-93 - CAS 139298-40-1 - Calbiochem Certificates of Analysis

TitleLot Number
422708

References

Reference overview
Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

Brochure

Title
Calmodulin and Related Products Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-November-2009 RFH
Synonyms2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
DescriptionCell-permeable, reversible, and competitive inhibitor of rat brain Ca+2/calmodulin-dependent protein kinase II (Ki = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
FormOff-white solid
CAS number139298-40-1
Chemical formulaC₂₆H₂₉CIN₂O₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Irritant
ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

Related Products & Applications

Alternative Products

Catalog Number Description  
422711 KN-93, Water-Soluble - Calbiochem Show Pricing & Availability

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors