422625 KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem

422625
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Key Specifications Table

Empirical FormulaCAS #
C₁₆H₁₈N₂O₇S 749872-43-3

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422625-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.
      Catalogue Number422625
      Brand Family Calbiochem®
      Synonyms2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate
      References
      ReferencesBialkowska, A., et al. 2011. Mol. Cancer Ther. 10, 2043.
      Product Information
      CAS number749872-43-3
      FormOff-white solid
      Hill FormulaC₁₆H₁₈N₂O₇S
      Chemical formulaC₁₆H₁₈N₂O₇S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      422625

      References

      Reference overview
      Bialkowska, A., et al. 2011. Mol. Cancer Ther. 10, 2043.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2013 JSW
      Synonyms2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate
      DescriptionA cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number749872-43-3
      Chemical formulaC₁₆H₁₈N₂O₇S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBialkowska, A., et al. 2011. Mol. Cancer Ther. 10, 2043.