530537 JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - Calbiochem

530537
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₈H₂₃NO₃

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
5.30537.0001
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530537
      Brand Family Calbiochem®
      SynonymsKDM4 Inhibitor
      References
      ReferencesSchiller, R., et al. 2014. ChemMedChem. 9,566.
      Product Information
      FormGrey-green solid
      Hill FormulaC₁₈H₂₃NO₃
      Chemical formulaC₁₈H₂₃NO₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetKDM4
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Schiller, R., et al. 2014. ChemMedChem. 9,566.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-June-2014 JSW
      SynonymsKDM4 Inhibitor
      DescriptionA cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.
      FormGrey-green solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₂₃NO₃
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchiller, R., et al. 2014. ChemMedChem. 9,566.