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420203 JMJD Histone Demethylase Inhibitor IV, Methylstat - CAS 1310877-95-2 - Calbiochem

420203
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Key Specifications Table

Empirical FormulaCAS #
C₂₈H₃₁N₃O61310877-95-2

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420203-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound (Cat. No. 420202) that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3 = 10.3 and 8.6 µM in KYSE150 cells, and 6.7 and 6.3 µM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2 µM.
      Catalogue Number420203
      Brand Family Calbiochem®
      Synonyms(E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, JHDM Inhibitor IV
      References
      ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.
      Product Information
      CAS number1310877-95-2
      FormOff-white powder
      Hill FormulaC₂₈H₃₁N₃O6
      Chemical formulaC₂₈H₃₁N₃O6
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥96% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      JMJD Histone Demethylase Inhibitor IV, Methylstat - CAS 1310877-95-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      JMJD Histone Demethylase Inhibitor IV, Methylstat - CAS 1310877-95-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      420203

      References

      Reference overview
      Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2013 JSW
      Synonyms(E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, JHDM Inhibitor IV
      DescriptionA methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound (Cat. No. 420202) that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3 = 10.3 and 8.6 µM in KYSE150 cells, and 6.7 and 6.3 µM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2 µM.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1310877-95-2
      Chemical formulaC₂₈H₃₁N₃O6
      Structure formulaStructure formula
      Purity≥96% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.