420145 JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem

420145
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Empirical FormulaCAS #
C₂₃H₂₀ClN₃O 796041-65-1

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420145-25MG
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      25 mg
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      Description
      OverviewA cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit the kinase activity of JAK3 (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1/3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. Reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 µM, respectively) in vitro and be efficacious in ameliorating delayed hypersensitivity reaction in mice (by ~78% with a daily oral dose of 50 mg/kg) and in prolonging the survival of heart transplant-recipient rats (by >3-fold with 60 mg/kg/day, p.o.) in vivo.
      Catalogue Number420145
      Brand Family Calbiochem®
      SynonymsN-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
      References
      ReferencesCarbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
      Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.
      Product Information
      CAS number796041-65-1
      FormWhite solid
      Hill FormulaC₂₃H₂₀ClN₃O
      Chemical formulaC₂₃H₂₀ClN₃O
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special Instructionsfollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      420145

      References

      Reference overview
      Carbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
      Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      SynonymsN-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
      DescriptionA cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit the kinase activity of JAK3 (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1/3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. Reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 µM, respectively) in vitro and be efficacious in ameliorating delayed hypersensitivity reaction in mice (by ~78% with a daily oral dose of 50 mg/kg) and in prolonging the survival of heart transplant-recipient rats (by >3-fold with 60 mg/kg/day, p.o.) in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number796041-65-1
      Chemical formulaC₂₃H₂₀ClN₃O
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special Instructionsfollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCarbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
      Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.