407617 Interleukin-1β, Mouse, Recombinant, E. coli

407617
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407617-5UG
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      Description
      OverviewRecombinant, mouse interleukin-1β expressed in E. coli. Suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing.
      Catalogue Number407617
      Brand Family Calbiochem®
      References
      ReferencesChun, S.Y., et al. 1995. Endocrinology 136, 3120.
      Weidmann, B., et al. 1994. Nature 370, 434.
      Dinarello, C.A., and Wolff, S.M. 1993. N. Engl. J. Med. 328, 106.
      Product Information
      FormLyophilized
      FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀= 5-10 pg/ml as measured in a cell proliferation assay
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-1β
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNM9740000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Interleukin-1β, Mouse, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-1β, Mouse, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407617

      References

      Reference overview
      Chun, S.Y., et al. 1995. Endocrinology 136, 3120.
      Weidmann, B., et al. 1994. Nature 370, 434.
      Dinarello, C.A., and Wolff, S.M. 1993. N. Engl. J. Med. 328, 106.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      DescriptionRecombinant, mouse interleukin-1β expressed in E. coli. Suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing. Interleukin-1 is a protein produced by stimulated macrophages and many other cell types. The following biological activities are attributed to IL-1: activation of T cells resulting in the production of IL-2 and expression of IL-2 receptors; initiation of Acute Phase Response by induction of hepatic protein synthesis; increased proteolysis of muscle proteins, amino acid mobilization, and caloric and oxygen utilization; induction of bone resorption; stimulation of fibroblast proliferation; induction of slow-wave sleep; fever production; induction of prostaglandin and leukotriene production; stimulation of thymocyte proliferation; induction of B cell proliferation and maturation and increased immunoglobulin synthesis; induction of collagenase and other proteinases in synovial fibroblasts and articular chrondrocytes, suggesting a role in pathological states such as arthritis; activation of neutrophils. 1 µg is equivalent to 1.1 x 106 WHO units.
      FormLyophilized
      FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
      RTECSNM9740000
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-1β
      Biological activityED₅₀= 5-10 pg/ml as measured in a cell proliferation assay
      SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
      Toxicity Standard Handling
      Merck USA index14, 4993
      ReferencesChun, S.Y., et al. 1995. Endocrinology 136, 3120.
      Weidmann, B., et al. 1994. Nature 370, 434.
      Dinarello, C.A., and Wolff, S.M. 1993. N. Engl. J. Med. 328, 106.

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      Categories

      Life Science Research > Proteins and Enzymes > Other Proteins