407611 Interleukin-1α, Human, Recombinant, E. coli

407611
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407611-2UG
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      Plastic ampoule 2 μg
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      Description
      OverviewRecombinant, human interleukin-1α expressed in E. coli. Potent stimulator of bone resorption and stimulator of nuclear phospholipase C. Induces nitric oxide synthase.
      Catalogue Number407611
      Brand Family Calbiochem®
      References
      ReferencesTsan, M.F., and White, J.E. 1994. Am. J. Physiol. 266, L316.
      Kilbourn, R.G., et al. 1992. J. Natl. Cancer Inst. 84, 1008.
      Dinarello, C.A., et al. 1991. Blood 77, 1627.
      Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
      Symons, J.A., et al. 1987. In Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al. Eds.) Oxford IRL Press, p. 272.
      March, C.J., et al. 1985. Nature 315, 641.
      Kampschmidt, R.F. 1984. J. Leuk. Biol. 36, 341.
      Product Information
      FormLyophilized
      FormulationLyophilized from sterile-filtered 20 mM Tris-HCl, 50 µg BSA/µg IL-1α, pH 8.3.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = 3-7 pg/ml as measured in a cell proliferation assay.
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-1α
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNM9739900
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Interleukin-1α, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-1α, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407611

      References

      Reference overview
      Tsan, M.F., and White, J.E. 1994. Am. J. Physiol. 266, L316.
      Kilbourn, R.G., et al. 1992. J. Natl. Cancer Inst. 84, 1008.
      Dinarello, C.A., et al. 1991. Blood 77, 1627.
      Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
      Symons, J.A., et al. 1987. In Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al. Eds.) Oxford IRL Press, p. 272.
      March, C.J., et al. 1985. Nature 315, 641.
      Kampschmidt, R.F. 1984. J. Leuk. Biol. 36, 341.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      DescriptionRecombinant, human interleukin-1α expressed in E. coli. A 159 amino acid polypeptide derived from mature IL-1α. Synthesized in vivo as a 271 amino acid residue (31 kDa) precursor that is subsequently cleaved into the mature polypeptide. Shows ~25% amino acid sequence identity with IL-1β, a distinct gene product sharing the same cell surface receptors as IL-1α. Produced by activated macrophages and many other cell types, the IL-1 proteins mediate a variety of effects on the differentiation and function of many cell types involved in inflammatory and immune responses. Potent stimulator of bone resorption and stimulator of nuclear phospholipase C. Induces nitric oxide synthase. Effects include stimulation of T-cell, B-cell, neutrophil, and fibroblast proliferation; induction of prostaglandin, leukotriene, and acute-phase hepatic protein synthesis; induction of proteinases in synovial fibroblasts and articular chondrocytes. IL-1 is also known to induce fever, slow-wave sleep, and bone resorption. 1 µg is equivalent to 1.6 x 105 WHO units.
      FormLyophilized
      FormulationLyophilized from sterile-filtered 20 mM Tris-HCl, 50 µg BSA/µg IL-1α, pH 8.3.
      RTECSNM9739900
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-1α
      Biological activityED₅₀ = 3-7 pg/ml as measured in a cell proliferation assay.
      SolubilityReconstitute with sterile PBS containing ≥0.1% HSA or BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
      Toxicity Standard Handling
      Merck USA index14, 4993
      ReferencesTsan, M.F., and White, J.E. 1994. Am. J. Physiol. 266, L316.
      Kilbourn, R.G., et al. 1992. J. Natl. Cancer Inst. 84, 1008.
      Dinarello, C.A., et al. 1991. Blood 77, 1627.
      Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
      Symons, J.A., et al. 1987. In Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al. Eds.) Oxford IRL Press, p. 272.
      March, C.J., et al. 1985. Nature 315, 641.
      Kampschmidt, R.F. 1984. J. Leuk. Biol. 36, 341.

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      Categories

      Life Science Research > Proteins and Enzymes > Other Proteins