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506148 InSolution™ p38 MAP Kinase Inhibitor III - Calbiochem

506148
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₂₁FN₄S

Pricing & Availability

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506148-1MG
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      Plastic ampoule 1 mg
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      Description
      Catalogue Number506148
      Brand Family Calbiochem®
      References
      ReferencesLaufer, S.A., et al. 2003. J. Med. Chem. 46, 3230.
      Product Information
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (1 mg/247 µl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506121) in DMSO.
      Hill FormulaC₂₃H₂₁FN₄S
      Chemical formulaC₂₃H₂₁FN₄S
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution p38 MAP Kinase Inhibitor III, CAS 581098-48-8, is a 10 mM solution in DMSO. A cell-permeable, potent, selective, ATP-competitive p38 MAP kinase inhibitor (IC50 = 380 nM for p38α).
      Biological Information
      Primary Targetp38 MAP kinase
      Primary Target IC<sub>50</sub>0.38 µM for p38α; 0.16 and 0.039 µM in suppressing LPS-induced TNF-α and IL-1β release, respectively, in human PBMC; ED50 = 1.33 mg/kg in suppressing LPS-induced TNF-α release in mouse
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ p38 MAP Kinase Inhibitor III - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ p38 MAP Kinase Inhibitor III - Calbiochem Certificates of Analysis

      TitleLot Number
      506148

      References

      Reference overview
      Laufer, S.A., et al. 2003. J. Med. Chem. 46, 3230.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-August-2008 RFH
      DescriptionA cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 380 nM for p38α). Shown to effectively suppress LPS-induced cytokine release in vitro (IC50 = 160 nM for TNF-α release and 39 nM for IL-1β release, human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-α release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models.
      FormLiquid
      FormulationA 10 mM (1 mg/247 µl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506121) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₂₁FN₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Standard Handling
      ReferencesLaufer, S.A., et al. 2003. J. Med. Chem. 46, 3230.