509721 InSolution™ Vitamin D3, 1α, 25-Dihydroxy- - Calbiochem

509721
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₇H₄₄O₃

Pricing & Availability

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5.09721.0001
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      Glass bottle 50 μg
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      Description
      Catalogue Number509721
      Brand Family Calbiochem®
      Synonyms1,25-(OH)₂-D₃
      References
      ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Mathieu, C., et al. 1994. Diabetologica 37, 552.
      Thomasset, M. 1994. Pathol. Biol. 42, 163.
      Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
      Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
      Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
      Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
      Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
      Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
      DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
      Product Information
      FormLiquid
      FormulationA 1 mM (50 ug/112 µL) solution of Vitamin D3, 1α, 25-Dihydroxy- (Cat. No. 679101) in DMSO.
      Hill FormulaC₂₇H₄₄O₃
      Chemical formulaC₂₇H₄₄O₃
      Hygroscopic Hygroscopic
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targetvitamin D receptor
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Vitamin D3, 1α, 25-Dihydroxy- - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Mathieu, C., et al. 1994. Diabetologica 37, 552.
      Thomasset, M. 1994. Pathol. Biol. 42, 163.
      Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
      Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
      Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
      Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
      Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
      Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
      DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2014 JSW
      Synonyms1,25-(OH)₂-D₃
      DescriptionActive hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D3. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.
      FormLiquid
      FormulationA 1 mM (50 ug/112 µL) solution of Vitamin D3, 1α, 25-Dihydroxy- (Cat. No. 679101) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₇H₄₄O₃
      Purity≥99% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Mathieu, C., et al. 1994. Diabetologica 37, 552.
      Thomasset, M. 1994. Pathol. Biol. 42, 163.
      Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
      Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
      Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
      Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
      Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
      Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
      DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.