553508 InSolution™ Rac1 Inhibitor - Calbiochem

553508
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₄H₃₅N₇ • 3HCl

Pricing & Availability

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553508-5MG
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      Plastic ampoule 5 mg
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      Description
      Catalogue Number553508
      Brand Family Calbiochem®
      References
      ReferencesDesire, L., et al. 2005. J. Biol. Chem. 280, 37516.
      Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
      Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.

      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
      Hill FormulaC₂₄H₃₅N₇ • 3HCl
      Chemical formulaC₂₄H₃₅N₇ • 3HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRac1
      Primary Target IC<sub>50</sub>~50 µM interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1
      Purity≥93% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Rac1 Inhibitor - Calbiochem Certificates of Analysis

      TitleLot Number
      553508

      References

      Reference overview
      Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
      Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
      Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.

      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-December-2010 JSW
      DescriptionA cell-permeable pyrimidine compound that specifically inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~ 50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Also shown to effectively inhibit Rac1 and Rac2 activation in Lin- c-kit+ bone marrow cells stimulated with SDF-1α (effective intraperitoneal dose of 1mg/kg). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.
      FormLiquid
      FormulationA 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₃₅N₇ • 3HCl
      Structure formulaStructure formula
      Purity≥93% by HPLC
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesDesire, L., et al. 2005. J. Biol. Chem. 280, 37516.
      Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
      Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.