500582 InSolution™ Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

500582
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Key Specifications Table

Empirical FormulaCAS #
C₃₆H₅₆O₈ 16561-29-8

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      Description
      OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
      Catalogue Number500582
      Brand Family Calbiochem®
      Synonyms12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA
      References
      ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
      Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
      Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
      Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
      Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
      Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
      Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
      Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
      Perchellet, J. 1985. Carcinogenesis 6, 567.
      Nishizuka, Y. 1984. Science 255, 1365.
      Mastro, A. 1982. Lymphokines 6, 263.
      Product Information
      CAS number16561-29-8
      FormLiquid
      FormulationA 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.
      Hill FormulaC₃₆H₅₆O₈
      Chemical formulaC₃₆H₅₆O₈
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Secondary targetCa2+-ATPase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
      Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
      Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
      Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
      Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
      Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
      Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
      Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
      Perchellet, J. 1985. Carcinogenesis 6, 567.
      Nishizuka, Y. 1984. Science 255, 1365.
      Mastro, A. 1982. Lymphokines 6, 263.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2013 JSW
      Synonyms12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA
      DescriptionMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
      FormLiquid
      FormulationA 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number16561-29-8
      Chemical formulaC₃₆H₅₆O₈
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.
      Toxicity Irritant
      ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
      Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
      Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
      Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
      Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
      Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
      Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
      Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
      Perchellet, J. 1985. Carcinogenesis 6, 567.
      Nishizuka, Y. 1984. Science 255, 1365.
      Mastro, A. 1982. Lymphokines 6, 263.