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420297 InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem

420297
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
97161-97-2C₂₇H₂₁N₃O₅

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420297-100UG
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      Plastic ampoule 100 μg
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      Description
      Catalogue Number420297
      Brand Family Calbiochem®
      References
      ReferencesChin, L.S., et al. 1999. Cancer Invest. 17, 391.
      Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
      Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
      Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
      Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
      Tapley, P., et al. 1992. Oncogene 7, 371.
      Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
      Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
      Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
      Product Information
      CAS number97161-97-2
      ATP CompetitiveY
      FormLiquid
      FormulationA 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO.
      Hill FormulaC₂₇H₂₁N₃O₅
      Chemical formulaC₂₇H₂₁N₃O₅
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCaM kinase II
      Primary Target K<sub>i</sub>1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      420297

      References

      Reference overview
      Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
      Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
      Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
      Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
      Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
      Tapley, P., et al. 1992. Oncogene 7, 371.
      Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
      Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
      Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

      Citations

      Title
    • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-July-2008 JSW
      DescriptionA cell-permeable protein kinase inhibitor that inhibits CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 17 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), and protein kinase G (Ki = 20 nM). Also acts as a potent inhibitor (IC50 = 3 nM) of the tyrosine protein kinase activity of the NGF receptor gp 140trk, the product of the trk protooncogene. Also inhibits the kinase activity of its transforming alleles, the trk oncogenes, and of the related neurotrophin receptors gp 145trkB and gp 145trkC. Induces apoptosis and cell cycle arrest by inhibiting Cdc2 and Cdc25c.
      FormLiquid
      FormulationA 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number97161-97-2
      Chemical formulaC₂₇H₂₁N₃O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.
      Toxicity Irritant
      ReferencesChin, L.S., et al. 1999. Cancer Invest. 17, 391.
      Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
      Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
      Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
      Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
      Tapley, P., et al. 1992. Oncogene 7, 371.
      Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
      Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
      Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
      Citation
    • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
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      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
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