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401484 InSolution™ IKK-2 Inhibitor IV - Calbiochem

401484
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₂H₁₀FN₃O₂S

Pricing & Availability

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401484-500UG
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      Plastic ampoule 500 μg
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      Description
      Catalogue Number401484
      Brand Family Calbiochem®
      References
      ReferencesPodolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
      Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
      Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.
      Product Information
      ATP CompetitiveY
      FormClear pale yellow Liquid
      FormulationA 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
      Hill FormulaC₁₂H₁₀FN₃O₂S
      Chemical formulaC₁₂H₁₀FN₃O₂S
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIKK-2
      Primary Target IC<sub>50</sub>18 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ IKK-2 Inhibitor IV - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ IKK-2 Inhibitor IV - Calbiochem Certificates of Analysis

      TitleLot Number
      401484

      References

      Reference overview
      Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
      Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
      Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      DescriptionIKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC50 = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).
      FormClear pale yellow Liquid
      FormulationA 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₂H₁₀FN₃O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Irritant
      ReferencesPodolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
      Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
      Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.