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531399 IRE1 Inhibitor IV, A-106

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      Glass bottle 25 mg
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      OverviewA cell permeable naphthaldehyde based compound that specifically targets the RNAse domain of IRE-1 (ERN1) and blocks the activation of X-box binding protein 1 (XBP-1). Shown to be equipotent to its parent compound, STF-083010. Blocks IRE-1 RNase activity via the formation of a stable Schiff base with K907 in the RNase domain of IRE-1, which prevents splicing of XBP-1mRNA. Downregulation of XBP-1 in Em-TCL1 CLL cells leads to apoptosis (~50 to 100 µM). Blocks the proliferation and survival of patient-derived pre-B ALL cells (10 to 50 thousand cells) in sub-lethally irradiated NOD/SCID mice in a dose-dependent manner.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531399
      Brand Family Calbiochem®
      SynonymsERN1 Inhibitor, A106
      ReferencesKriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.
      Product Information
      FormYellowish-white powder
      Hill FormulaC₁₁H₈O₂
      Chemical formulaC₁₁H₈O₂
      Quality LevelMQ100
      Biological Information
      Primary TargetIRE1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information


      IRE1 Inhibitor IV, A-106 SDS


      Safety Data Sheet (SDS) 


      Reference overview
      Kriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.