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531237 IRAK4 Inhibitor, Compound 26 - Calbiochem

IRAK4 Inhibitor, Compound 26 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Interleukin-1 Receptor Associated Kinase 4 Inhibitor

Primary Target: IRAK4
531237
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₅H₂₇N₅O₂

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      Description
      OverviewA cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94 pM). Displays much reduced potency against IRAK1 (IC50 = 65 nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling. Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk). Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100 μg/ml at pH 7.4).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531237
      Brand Family Calbiochem®
      SynonymsInterleukin-1 Receptor Associated Kinase 4 Inhibitor
      References
      ReferencesTumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.
      Product Information
      CAS number1604034-71-0
      FormPale yellow powder
      Hill FormulaC₂₅H₂₇N₅O₂
      Chemical formulaC₂₅H₂₇N₅O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIRAK4
      Primary Target IC<sub>50</sub>94 pM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      IRAK4 Inhibitor, Compound 26 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Tumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-August-2017 JSW
      SynonymsInterleukin-1 Receptor Associated Kinase 4 Inhibitor
      DescriptionA cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94 pM). Displays much reduced potency against IRAK1 (IC50 = 65 nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling. Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk). Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100 μg/ml at pH 7.4).
      FormPale yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1604034-71-0
      Chemical formulaC₂₅H₂₇N₅O₂
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.