401486 IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem

401486
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₈H₂₉N₅OS 873225-46-8

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401486-1MG
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      Glass bottle 1 mg
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      Description
      OverviewA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Also available as a 10 mM solution in DMSO (Cat. No. 505378).
      Catalogue Number401486
      Brand Family Calbiochem®
      SynonymsIKK 16
      References
      ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.
      Product Information
      CAS number873225-46-8
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₂₈H₂₉N₅OS
      Chemical formulaC₂₈H₂₉N₅OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationIKK Inhibitor VII, CAS 873225-46-8, is a cell-permeable, potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex & IKK-1, respectively).
      Biological Information
      Primary TargetIKK
      Primary Target IC<sub>50</sub>40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      401486

      References

      Reference overview
      Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsIKK 16
      DescriptionA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number873225-46-8
      Chemical formulaC₂₈H₂₉N₅OS
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.