3779 Histamine, Free Base - CAS 51-45-6 - Calbiochem

3779
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₅H₉N₃ 51-45-6

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3779-1GM
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      Glass bottle 1 gm
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      3779-5GM
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          Description
          OverviewA potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H1 receptors leads to Ca2+ mobilization, whereas histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.
          Catalogue Number3779
          Brand Family Calbiochem®
          Synonyms2-(4-Imidazolyl)ethylamine
          References
          ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
          Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
          Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
          Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
          Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
          Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
          Product Information
          CAS number51-45-6
          FormWhite solid
          Hill FormulaC₅H₉N₃
          Chemical formulaC₅H₉N₃
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥97% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMS1050000
          Safety Information
          R PhraseR: 22-36/37/38-42/43

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 26-36/37-22

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing and gloves.
          Do not breathe dust.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Histamine, Free Base - CAS 51-45-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Histamine, Free Base - CAS 51-45-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          3779

          References

          Reference overview
          Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
          Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
          Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
          Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
          Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
          Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-June-2011 JSW
          Synonyms2-(4-Imidazolyl)ethylamine
          DescriptionA potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number51-45-6
          RTECSMS1050000
          Chemical formulaC₅H₉N₃
          Structure formulaStructure formula
          Purity≥97% by TLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 4719
          ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
          Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
          Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
          Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
          Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
          Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.