376817 Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem

376817
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₃H₃BrO₃ 1113-59-3

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376817-100MG
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      100 mg
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      Description
      OverviewA cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.
      Catalogue Number376817
      Brand Family Calbiochem®
      Synonyms3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid
      References
      ReferencesBujis, M., et al. 2009. Invest. New Drugs 27, 120.
      Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
      Hulleman, E., et al. 2009. Blood. 113, 2014;
      Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
      Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
      Yun, J., et al. 2009. Science. 325, 1555.
      Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
      Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.
      Product Information
      CAS number1113-59-3
      EC number214-206-5
      FormWhite crystalline solid
      Hill FormulaC₃H₃BrO₃
      Chemical formulaC₃H₃BrO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by Titration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUZ0840000
      Safety Information
      R PhraseR: 34

      Causes burns.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Corrosive
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      376817

      References

      Reference overview
      Bujis, M., et al. 2009. Invest. New Drugs 27, 120.
      Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
      Hulleman, E., et al. 2009. Blood. 113, 2014;
      Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
      Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
      Yun, J., et al. 2009. Science. 325, 1555.
      Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
      Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-December-2010 RFH
      Synonyms3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid
      DescriptionA cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.
      FormWhite crystalline solid
      CAS number1113-59-3
      RTECSUZ0840000
      EC number214-206-5
      Chemical formulaC₃H₃BrO₃
      Structure formulaStructure formula
      Purity≥97% by Titration
      SolubilityDMSO (100 mg/ml) or dH₂O (100 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Corrosive
      ReferencesBujis, M., et al. 2009. Invest. New Drugs 27, 120.
      Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
      Hulleman, E., et al. 2009. Blood. 113, 2014;
      Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
      Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
      Yun, J., et al. 2009. Science. 325, 1555.
      Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
      Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.