374000 Helenalin, A. chamissonis ssp. foliosa

374000
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374000-500UG
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      Glass bottle 500 μg
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      Description
      OverviewA cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κB activation/nuclear translocation or IκB dissociation/degradation. An excellent research tool for studying NF-κB-mediated biological processes both in cultures in vitro and in animals in vivo.
      Catalogue Number374000
      Brand Family Calbiochem®
      References
      ReferencesBoulanger, D., et al. 2007. Vet. Microbiol. 119, 330.
      Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun. 346, 314.
      Huang, P.R., et al. 2005. Cancer Lett. 227, 169.
      Lyss, G., et al. 1998. J. Biol. Chem. 273, 33508.
      Lyss, G., et al. 1997. Biol. Chem. 378, 951.
      Product Information
      CAS number6754-13-8
      FormWhite to off-white solid
      Hill FormulaC₁₅H₁₈O₄
      Chemical formulaC₁₅H₁₈O₄
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSBD9630000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Toxic
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Helenalin, A. chamissonis ssp. foliosa Certificates of Analysis

      TitleLot Number
      374000

      References

      Reference overview
      Boulanger, D., et al. 2007. Vet. Microbiol. 119, 330.
      Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun. 346, 314.
      Huang, P.R., et al. 2005. Cancer Lett. 227, 169.
      Lyss, G., et al. 1998. J. Biol. Chem. 273, 33508.
      Lyss, G., et al. 1997. Biol. Chem. 378, 951.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-April-2011 RFH
      DescriptionA cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κB activation/nuclear translocation or IκB dissociation/degradation. An excellent research tool for studying NF-κB-mediated biological processes both in cultures in vitro and in animals in vivo.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number6754-13-8
      RTECSBD9630000
      Chemical formulaC₁₅H₁₈O₄
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 4626
      ReferencesBoulanger, D., et al. 2007. Vet. Microbiol. 119, 330.
      Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun. 346, 314.
      Huang, P.R., et al. 2005. Cancer Lett. 227, 169.
      Lyss, G., et al. 1998. J. Biol. Chem. 273, 33508.
      Lyss, G., et al. 1997. Biol. Chem. 378, 951.