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531067 HSP70 Inhibitor, PES-Cl - Calbiochem

531067
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₈H₆ClNO₂S

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable chlorophenylethynylsulfonamide compound that binds directly to the substrate-binding domain of heat shock protein 70 (HSP70) and disrupts its interaction with client proteins. Impairs the activity of the anaphase promoting complex/cyclosome (APC/C) in cell-free extracts. Arrests cell cycle at G2/M phase and preferentially induces genomic instability in cancer cells (IC50 = 2 to 5 µM in melanoma cell lines). Exhibits much reduced toxicity in non-transformed cells (IC50 >100 µM in primary melanocytes). Induces apoptosis and inhibits autophagy as evidenced by increased p62SQSTM1 and LC3 accumulation. Also, shown to extend life in murine models of pre-B cell lymphoma.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531067
      Brand Family Calbiochem®
      SynonymsHeat Shock Protein 70 Inhibitor
      References
      ReferencesBalaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
      Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.
      Product Information
      FormWhite powder
      Hill FormulaC₈H₆ClNO₂S
      Chemical formulaC₈H₆ClNO₂S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHSP70
      Primary Target IC<sub>50</sub>2-5 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      HSP70 Inhibitor, PES-Cl - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Balaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
      Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-August-2014 JSW
      SynonymsHeat Shock Protein 70 Inhibitor
      DescriptionA cell-permeable chlorophenylethynylsulfonamide compound that binds directly to the substrate-binding domain of heat shock protein 70 (HSP70) and disrupts its interaction with client proteins. Impairs the activity of the anaphase promoting complex/cyclosome (APC/C) in cell-free extracts. Arrests cell cycle at G2/M phase and preferentially induces genomic instability in cancer cells (IC50 = 2 to 5 µM in melanoma cell lines). Exhibits much reduced toxicity in non-transformed cells (IC50 >100 µM in primary melanocytes). Induces apoptosis and inhibits autophagy as evidenced by increased p62SQSTM1 and LC3 accumulation. Also, shown to extend life in murine models of pre-B cell lymphoma.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₈H₆ClNO₂S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBalaburski, G., et al. 2013. Mol. Cancer Res. 11, 1.
      Budina-Kolomets, A. et al. 2013. Cancer Biol. Ther. 15, 194.