400083 HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

400083
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₆H₂₉NO₅ 934593-90-5

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400083-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein. Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Also available as a 25 mM solution in DMSO (Cat. No. 400092).
      Catalogue Number400083
      Brand Family Calbiochem®
      SynonymsCAY10585, Hypoxia-Inducible Factor-1 Inhibitor, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, LW6
      References
      ReferencesLee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
      Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
      Product Information
      CAS number934593-90-5
      FormLight beige powder
      Hill FormulaC₂₆H₂₉NO₅
      Chemical formulaC₂₆H₂₉NO₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      400083

      References

      Reference overview
      Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
      Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-December-2013 JSW
      SynonymsCAY10585, Hypoxia-Inducible Factor-1 Inhibitor, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, LW6
      DescriptionA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
      FormLight beige powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number934593-90-5
      Chemical formulaC₂₆H₂₉NO₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
      Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.