508194 HDAC6 Inhibitor III - Calbiochem

508194
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₁₉N₃O₃

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, quinazolin-4-one based hydroxamic acid containing compound that acts as a potent and selective inhibitor of histone deacetylase 6 (HDAC6; IC50 = 29 nM). Exhibits high selectivity over other HDACs (IC50 = 1.88, 6.45, 1.75, and 4.08 µM for HDAC1, 2, 8, and 11, respectively). Does not affect hERG activity (>10 µM) or p450 activity (IC50 > 6.5 µM). Blocks b-amyloid (Ab) aggregation in the presence of zinc (IC50 = 9.5 µM) and improves learning-based performance in mice. Induces neurite outgrowth (EC50 = 7.3 and 9.2 µM in PC12 and SH-SY5Y cells, respectively) and enhances synaptic activity (EC50 = 6.5 and 6.8 µM in PC12 and SH-SY5Y cells, respectively). Shown to enhance acetylated a-tubulin levels in hippocampus region of mice with Ab lesions.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508194
      Brand Family Calbiochem®
      References
      ReferencesYu, C.W., et al. 2013. J. Med. Chem. 56, 6775.
      Product Information
      FormCream powder
      Hill FormulaC₂₀H₁₉N₃O₃
      Chemical formulaC₂₀H₁₉N₃O₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHDAC6
      Primary Target IC<sub>50</sub>29 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      HDAC6 Inhibitor III - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Yu, C.W., et al. 2013. J. Med. Chem. 56, 6775.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2014 JSW
      DescriptionA cell-permeable, quinazolin-4-one based hydroxamic acid containing compound that acts as a potent and selective inhibitor of histone deacetylase 6 (HDAC6; IC50 = 29 nM). Exhibits high selectivity over other HDACs (IC50 = 1.88, 6.45, 1.75, and 4.08 µM for HDAC1, 2, 8, and 11, respectively). Does not affect hERG activity (>10 µM) or p450 activity (IC50 > 6.5 µM). Blocks b-amyloid (Ab) aggregation in the presence of zinc (IC50 = 9.5 µM) and improves learning-based performance in mice. Induces neurite outgrowth (EC50 = 7.3 and 9.2 µM in PC12 and SH-SY5Y cells, respectively) and enhances synaptic activity (EC50 = 6.5 and 6.8 µM in PC12 and SH-SY5Y cells, respectively). Shown to enhance acetylated a-tubulin levels in hippocampus region of mice with Ab lesions.
      FormCream powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₁₉N₃O₃
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYu, C.W., et al. 2013. J. Med. Chem. 56, 6775.