370674 Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem

370674
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₀H₁₀BrN₅O₆PS · Na

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370674-5UMOL
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      Plastic ampoule 5 umol
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      Description
      OverviewA potent, cell-permeable, and metabolically stable inhibitor of protein kinase G (PKG; Ki = 4 µM). Acts as a cyclic nucleotide-gated channel agonist (EC50 = 173.5 µM). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Note: 5 µmol = 2.31 mg.
      Catalogue Number370674
      Brand Family Calbiochem®
      SynonymsRp-8-Br-cGMPS, Na, PKG Inhibitor II
      References
      ReferencesWei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
      Nakamura, A., et al. 1996. Br. J. Pharmacol. 117, 407.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Nakazawa, M., et al. 1994. Eur. J. Pharmacol. 253, 179.
      Zhuo, M., et al. 1994. Nature 368, 635.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₀H₁₀BrN₅O₆PS · Na
      Chemical formulaC₁₀H₁₀BrN₅O₆PS · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKG
      Primary Target K<sub>i</sub>4 µM against protein kinase G (PKG)
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem Certificates of Analysis

      TitleLot Number
      370674

      References

      Reference overview
      Wei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
      Nakamura, A., et al. 1996. Br. J. Pharmacol. 117, 407.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Nakazawa, M., et al. 1994. Eur. J. Pharmacol. 253, 179.
      Zhuo, M., et al. 1994. Nature 368, 635.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-January-2008 JSW
      SynonymsRp-8-Br-cGMPS, Na, PKG Inhibitor II
      DescriptionA potent cell-permeable, metabolically stable inhibitor of cGMP-dependent protein kinase (PKG). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases.
      FormLyophilized
      Chemical formulaC₁₀H₁₀BrN₅O₆PS · Na
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
      Nakamura, A., et al. 1996. Br. J. Pharmacol. 117, 407.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Nakazawa, M., et al. 1994. Eur. J. Pharmacol. 253, 179.
      Zhuo, M., et al. 1994. Nature 368, 635.