361568 GSK-3β Inhibitor XXV - Calbiochem

361568
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₅H₁₁ClN₄O₃

Pricing & Availability

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361568-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3β activity (IC50 = 17.1 nM) with excellent selectivity over Cdk2 (22% inhibition at 10 µM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15 mg/kg (i.p.) amounts.
      Catalogue Number361568
      Brand Family Calbiochem®
      Synonyms5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, M SEW00923SC
      References
      ReferencesKhanfar, M.A., et al. 2010. J. Med. Chem. 53, 8534.
      Product Information
      FormYellow solid
      Hill FormulaC₁₅H₁₁ClN₄O₃
      Chemical formulaC₁₅H₁₁ClN₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GSK-3β Inhibitor XXV - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Khanfar, M.A., et al. 2010. J. Med. Chem. 53, 8534.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-July-2012 JSW
      Synonyms5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, M SEW00923SC
      DescriptionA blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3β activity (IC50 = 17.1 nM) with excellent selectivity over Cdk2 (22% inhibition at 10 µM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15 mg/kg (i.p.) amounts.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₁₁ClN₄O₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKhanfar, M.A., et al. 2010. J. Med. Chem. 53, 8534.