361559 Sigma-AldrichGSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem
GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC₅₀ = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively).
More>> GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC₅₀ = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). Less<<Synonyms: 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile, CHIR99021
Recommended Products
Overview
Replacement Information |
---|
Key Specifications Table
CAS # | Empirical Formula |
---|---|
252917-06-9 | C₂₂H₁₈Cl₂N₈ |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
---|---|---|---|---|---|---|
361559-5MG |
|
Plastic ampoule | 5 mg |
|
— |
Description | |
---|---|
Overview | A cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). Exhibits little or no activity toward 46 other enzymes (IC50 >8.8 µM against 20 kinases and Ki ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). This compound is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 361571). |
Catalogue Number | 361559 |
Brand Family | Calbiochem® |
Synonyms | 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile, CHIR99021 |
Product Information | |
---|---|
CAS number | 252917-06-9 |
Form | White to beige solid |
Hill Formula | C₂₂H₁₈Cl₂N₈ |
Chemical formula | C₂₂H₁₈Cl₂N₈ |
Structure formula Image | |
Quality Level | MQ200 |
Applications |
---|
Biological Information | |
---|---|
Purity | ≥95% by HPLC |
Physicochemical Information |
---|
Dimensions |
---|
Materials Information |
---|
Toxicological Information |
---|
Safety Information according to GHS |
---|
Product Usage Statements |
---|
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Transport Information |
---|
Supplemental Information |
---|
Specifications |
---|
Global Trade Item Number | |
---|---|
Catalog Number | GTIN |
361559-5MG | 04055977214208 |
Documentation
GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem SDS
Title |
---|
GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem Certificates of Analysis
Title | Lot Number |
---|---|
361559 |
References
Reference overview |
---|
Mussmann, R., et al. 2007. J. Biol. Chem. 282, 12030. Ring, D.B., et al. 2003. Diabetes 52, 588. Bennett, C.N., et al. 2002. J. Biol. Chem. 277, 30998. Cline, G.W., et al. 2002. Diabetes 51, 2903. |