361550 GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

361550
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₆H₁₀BrN₃O₂ 667463-62-9

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361550-10MG
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      361550-1MG
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          361550-30MG
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              Description
              OverviewA cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available.
              Catalogue Number361550
              Brand Family Calbiochem®
              SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
              References
              ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
              Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
              Sato, N., et al. 2004. Nat. Med. 10, 55.
              Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
              Product Information
              CAS number667463-62-9
              ATP CompetitiveY
              FormPurple solid
              Hill FormulaC₁₆H₁₀BrN₃O₂
              Chemical formulaC₁₆H₁₀BrN₃O₂
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetGSK-3α/β
              Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
              Purity≥97% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 20/21/22

              Harmful by inhalation, in contact with skin and if swallowed.
              S PhraseS: 22-36/37

              Do not breathe dust.
              Wear suitable protective clothing and gloves.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped with Blue Ice or with Dry Ice
              Toxicity Carcinogenic / Teratogenic
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem Certificates of Analysis

              TitleLot Number
              361550

              References

              Reference overview
              Tseng, A-S., et al. 2006. Chem. Biol. 13, 957.
              Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
              Sato, N., et al. 2004. Nat. Med. 10, 55.
              Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

              Citations

              Title
            • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision03-April-2008 RFH
              SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
              DescriptionA cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes.
              FormPurple solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number667463-62-9
              Chemical formulaC₁₆H₁₀BrN₃O₂
              Structure formulaStructure formula
              Purity≥97% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Carcinogenic / Teratogenic
              ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
              Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
              Sato, N., et al. 2004. Nat. Med. 10, 55.
              Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
              Citation
            • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
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              Categories

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors