344847 Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem

344847
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₂H₂₅N₃O₃ 118974-02-0

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344847-250UG
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      Plastic ampoule 250 μg
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      Description
      OverviewA cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.
      Catalogue Number344847
      Brand Family Calbiochem®
      SynonymsNSC719655, FTC
      References
      ReferencesAllen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
      Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
      Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
      Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
      Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.
      Product Information
      CAS number118974-02-0
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₂₂H₂₅N₃O₃
      Chemical formulaC₂₂H₂₅N₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationFumitremorgin C, Aspergillus. Fumigatus, CAS 118974-02-0, is a cell-permeable chemo-sensitizing agent that inhibits BCRP/ABCG2 multidrug transport activity.
      Biological Information
      Primary TargetBCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      344847

      References

      Reference overview
      Allen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
      Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
      Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
      Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
      Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-May-2008 RFH
      SynonymsNSC719655, FTC
      DescriptionA cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.
      FormLyophilized
      Intert gas (Yes/No) Packaged under inert gas
      CAS number118974-02-0
      Chemical formulaC₂₂H₂₅N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesAllen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
      Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
      Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
      Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
      Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.