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344282 Forskolin, Coleus forskohlii in DMSO - Calbiochem

344282
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₂H₃₄O₇

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344282-5MG
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      Description
      OverviewThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. The solid form of this compound (Cat. No. 344270) is also available.
      Catalogue Number344282
      Brand Family Calbiochem®
      References
      ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
      Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
      Galli, C., et al. 1995. J. Neurosci. 15, 1172.
      Li, X., et al. 1995. Am. J. Physiol. 269, C986.
      Lomo, J., et al. 1995. J. Immunol. 154, 1634.
      Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
      Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
      Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
      Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
      Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
      Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
      Product Information
      FormLiquid
      FormulationA 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.
      Hill FormulaC₂₂H₃₄O₇
      Chemical formulaC₂₂H₃₄O₇
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Forskolin, Coleus forskohlii in DMSO - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Forskolin, Coleus forskohlii in DMSO - Calbiochem Certificates of Analysis

      TitleLot Number
      344282

      References

      Reference overview
      D'Orazio, J.A., et al. 2006. Nature 443, 340.
      Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
      Galli, C., et al. 1995. J. Neurosci. 15, 1172.
      Li, X., et al. 1995. Am. J. Physiol. 269, C986.
      Lomo, J., et al. 1995. J. Immunol. 154, 1634.
      Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
      Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
      Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
      Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
      Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
      Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-February-2012 RFH
      DescriptionThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
      FormLiquid
      FormulationA 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₃₄O₇
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
      Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
      Galli, C., et al. 1995. J. Neurosci. 15, 1172.
      Li, X., et al. 1995. Am. J. Physiol. 269, C986.
      Lomo, J., et al. 1995. J. Immunol. 154, 1634.
      Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
      Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
      Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
      Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
      Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
      Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.