341494 Ferrostatin-1 - Calbiochem

341494
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341494-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable 3,4-diaminoethylbenzoate-based antioxidant that effectively prevents Glutamate- (5 mM; 3 h) induced neurotoxicity in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus; [Fer-1] = 2 µM, added 0.5 h prior to Glutamate) and Erastin- (Cat. No. 329600; 50 µM; 24 h) induced HT-1080 death (EC50 = 60 nM) by blocking cytosolic and lipid ROS accumulation (by >80% at 0.5 µM in 10 µM Erastin-treated HT-1080 cells). Fer-1 does not prevent H2O2- (Cat. No. 386790) induced necrosis, STS- (Cat. Nos. 569396 & 569397) induced apoptosis, or Iron-independent oxidative death by Rotenone (Cat. No. 557368).
      Catalogue Number341494
      Brand Family Calbiochem®
      SynonymsFerrostatin1, Ethyl-3-amino-4-(cyclohexylamino)benzoate
      References
      ReferencesSkouta, R., et al. 2014. J. Am. Chem. Soc. 136, In press.
      Dixon, S.J., et al. 2012. Cell 149, 1060.
      Product Information
      FormTan solid
      Hill FormulaC₁₅H₂₂N₂O₂
      Chemical formulaC₁₅H₂₂N₂O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFree radical scavenger
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overview
      Skouta, R., et al. 2014. J. Am. Chem. Soc. 136, In press.
      Dixon, S.J., et al. 2012. Cell 149, 1060.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2013 JSW
      SynonymsFerrostatin1, Ethyl-3-amino-4-(cyclohexylamino)benzoate
      DescriptionA cell-permeable 3,4-diaminoethylbenzoate-based antioxidant ([DPPH]t=10 min/[DPPH]t=0 = 18.8 µM/50 µM; [Fer-1]t=0 = 50 µM) that effectively prevents Glutamate- (5 mM; 3 h) induced neurotoxicity (by PI staining 24 h after glutamate removal) in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus; [Fer-1] = 2 µM, added 0.5 h prior to Glutamate) and Erastin- (Cat. No. 329600; 50 µM; 24 h) induced HT-1080 death (EC50 = 60 nM) by blocking both cytosolic and lipid ROS accumulation (by >80% in 10 µM Erastin-treated HT-1080 cells; [Fer-1] = 0.5 µM) as assessed by ROS probes H2DCFDA (Cat. No. 287810) and C11-BODIPY, respectively. Fer-1 does not prevent H2O2- (Cat. No. 386790) induced necrosis, STS- (Cat. Nos. 569396 & 569397) induced apoptosis, or Iron-independent oxidative death by Rotenone (Cat. No. 557368).
      FormTan solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₂₂N₂O₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSkouta, R., et al. 2014. J. Am. Chem. Soc. 136, In press.
      Dixon, S.J., et al. 2012. Cell 149, 1060.