533684 Ferroptosis Inhibitor, Liproxstatin-1 - Calbiochem

533684
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₉H₂₁ClN₄·HCl

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable spiroquinoxalinamine derivative that specifically suppresses ferroptosis in glutathione peroxidase 4 (Gpx4) knockout cells (IC50 = 22 nM) and in Gpx -/- mice. However, it does not affect apoptosis induced by TNF-α, vinblatine, paclitaxel, and other anti-tumor agents and has no effect on H2O2 induced necrosis. Protects primary human renal proximal tubule epithelial cells from RSL3-induced cell death (~100 nM) and extends the survival in a murine model of acute renal failure (10 mg/kg, i.p.). Reduces tissue injury in an ischaemia/reperfusion-induced hepatic damage model. Exhibits favorable pharmacokinetic profile (t 1/2 = 4.6 h; total clearance of 66 ml/min/kg) without displaying any cytotoxicity (TC50 = 6 µM in HepG2 cells).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533684
      Brand Family Calbiochem®
      SynonymsN-(3-chlorobenzyl)-1ʹH-spiro[piperidine-4,2ʹ-quinoxalin]-3ʹ-amine hydrochloride
      References
      ReferencesFriedmann, A., et al. 2014. PNAS. 16, 1180.
      Product Information
      FormPink powder
      Hill FormulaC₁₉H₂₁ClN₄·HCl
      Chemical formulaC₁₉H₂₁ClN₄·HCl
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ferroptosis Inhibitor, Liproxstatin-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Friedmann, A., et al. 2014. PNAS. 16, 1180.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-November-2015 JSw
      SynonymsN-(3-chlorobenzyl)-1ʹH-spiro[piperidine-4,2ʹ-quinoxalin]-3ʹ-amine hydrochloride
      DescriptionA cell-permeable spiroquinoxalinamine derivative that specifically suppresses ferroptosis in glutathione peroxidase 4 (Gpx4) knockout cells (IC50 = 22 nM) and in Gpx -/- mice. However, it does not affect apoptosis induced by TNF-α, vinblatine, paclitaxel, and other anti-tumor agents and has no effect on H2O2 induced necrosis. Protects primary human renal proximal tubule epithelial cells from RSL3-induced cell death (~100 nM) and extends the survival in a murine model of acute renal failure (10 mg/kg, i.p.). Reduces tissue injury in an ischaemia/reperfusion-induced hepatic damage model. Exhibits favorable pharmacokinetic profile (t 1/2 = 4.6 h; total clearance of 66 ml/min/kg) without displaying any cytotoxicity (TC50 = 6 µM in HepG2 cells).
      FormPink powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉H₂₁ClN₄·HCl
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or H₂O (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFriedmann, A., et al. 2014. PNAS. 16, 1180.