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504684 Fenobam - CAS 57653-26-6 - Calbiochem

504684
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Key Specifications Table

Empirical FormulaCAS #
C₁₁H₁₁ClN₄O₂ 57653-26-6

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      Glass bottle 5 mg
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      Description
      OverviewA potent negative allosteric modulator highly selective for mGluR5 (IC50 = 87 nM; Kd = 54 nM and 31 nM at recombinant mGlu5 receptors of rat and human, respectively). Biologically active admitted orally or systematically. Frequently used for assessing the functional roles of mGlu5 receptors in a variety of brain functions (i.e. learning and memory, circadian rhythms, reward and decision making, and locomotion) and disorders (i.e. addition, depression, seizures, anxiety disorder, Parkinsons disease, Alzheimers disease, and Down syndrome). A leading therapeutic candidate for treatment of fragile X syndrome.
      Catalogue Number504684
      Brand Family Calbiochem®
      SynonymsN-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea
      References
      ReferencesPorter, R., et al. 2005. J. Pharmacol. Exp. Ther. 315, 711.
      Jacob, W., et al. 2009. Neuropharmacology 57, 97.
      Berry-Kravis, E., et al. 2009. J. Medical Genetics. 46, 266.
      Watterson, R., et al. 2012. Psychopharmacol. 2012, 1.
      Simonyi, A., et al. 2010. Eur. J. Pharmacol. 639, 17.
      Westmark, J., et al. 2010. J. Alzheimer's Disease 20, 1009.
      Product Information
      CAS number57653-26-6
      FormWhite solid
      Hill FormulaC₁₁H₁₁ClN₄O₂
      Chemical formulaC₁₁H₁₁ClN₄O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₅ receptors
      Primary Target IC<sub>50</sub>87 nM
      Primary Target K<sub>i</sub>54 nM and 31 nM at recombinant mGlu₅ receptors of rat and human, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Fenobam - CAS 57653-26-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Porter, R., et al. 2005. J. Pharmacol. Exp. Ther. 315, 711.
      Jacob, W., et al. 2009. Neuropharmacology 57, 97.
      Berry-Kravis, E., et al. 2009. J. Medical Genetics. 46, 266.
      Watterson, R., et al. 2012. Psychopharmacol. 2012, 1.
      Simonyi, A., et al. 2010. Eur. J. Pharmacol. 639, 17.
      Westmark, J., et al. 2010. J. Alzheimer's Disease 20, 1009.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      SynonymsN-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea
      DescriptionA potent negative allosteric modulator highly selective for mGluR5 (IC50 = 87 nM; Kd = 54 nM and 31 nM at recombinant mGlu5 receptors of rat and human, respectively). Biologically active admitted orally or systematically. Frequently used for assessing the functional roles of mGlu5 receptors in a variety of brain functions (i.e. learning and memory, circadian rhythms, reward and decision making, and locomotion) and disorders (i.e. addition, depression, seizures, anxiety disorder, Parkinsons disease, Alzheimers disease, and Down syndrome). A leading therapeutic candidate for treatment of fragile X syndrome.
      FormWhite solid
      CAS number57653-26-6
      Chemical formulaC₁₁H₁₁ClN₄O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPorter, R., et al. 2005. J. Pharmacol. Exp. Ther. 315, 711.
      Jacob, W., et al. 2009. Neuropharmacology 57, 97.
      Berry-Kravis, E., et al. 2009. J. Medical Genetics. 46, 266.
      Watterson, R., et al. 2012. Psychopharmacol. 2012, 1.
      Simonyi, A., et al. 2010. Eur. J. Pharmacol. 639, 17.
      Westmark, J., et al. 2010. J. Alzheimer's Disease 20, 1009.