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341251 Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem

A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 0.35 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CDK4/D1
341251
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
114719-57-2C₁₈H₁₁ClN₂O

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341251-1MG
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      Description
      OverviewA cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC50 = 0.35 µM). It inhibits Cdk6/D1 with much lower potency (IC50 = 3.4 µM) and has been shown not to affect the activities of several other Cdk’s (IC50 > 20 µM) and tyrosine kinases (IC50 > 10 µM). Part of its biological effects may also be attributed to its ability to intercalate into DNA. Has also been shown to display anti-microbial activity.
      Catalogue Number341251
      Brand Family Calbiochem®
      References
      ReferencesHormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
      Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
      Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.
      Product Information
      CAS number114719-57-2
      ATP CompetitiveY
      FormBrown solid
      Hill FormulaC₁₈H₁₁ClN₂O
      Chemical formulaC₁₈H₁₁ClN₂O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCDK4/D1
      Primary Target IC<sub>50</sub>0.35 µM against Cdk4/D1
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      341251

      References

      Reference overview
      Hormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
      Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
      Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      DescriptionA cell-permeable red pigment, originally isolated from a species of marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 350 nM). Reported to inhibit Cdk6/cyclin D1 with much lower potency (IC50 = 3.4 µM). Exhibits little to no effect on the activities of several other Cdk's (IC50 >20 µM) and tyrosine kinases (IC50 >10 µM). Biological effects are attributed, in part, to its ability to intercalate into DNA. Also displays anti-microbial activity.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number114719-57-2
      Chemical formulaC₁₈H₁₁ClN₂O
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (10 mg/ml) or Methanol (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesHormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
      Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
      Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.