341251
Sigma-AldrichFascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem
A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 0.35 µM).
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Description
Overview
A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC50 = 0.35 µM). It inhibits Cdk6/D1 with much lower potency (IC50 = 3.4 µM) and has been shown not to affect the activities of several other Cdk’s (IC50 > 20 µM) and tyrosine kinases (IC50 > 10 µM). Part of its biological effects may also be attributed to its ability to intercalate into DNA. Has also been shown to display anti-microbial activity.
Catalogue Number
341251
Brand Family
Calbiochem®
References
References
Hormann, A., et al. 2001. Bioorg. Med. Chem.9, 917. Kirsch, G., et al. 2000. J. Nat. Prod.63, 825. Soni, R., et al. 2000. Biochem. Biophys. Res. Commun.275, 877.
Product Information
CAS number
114719-57-2
ATP Competitive
Y
Form
Brown solid
Hill Formula
C₁₈H₁₁ClN₂O
Chemical formula
C₁₈H₁₁ClN₂O
Hygroscopic
Hygroscopic
Reversible
Y
Structure formula Image
Applications
Biological Information
Primary Target
CDK4/D1
Primary Target IC<sub>50</sub>
0.35 µM against Cdk4/D1
Purity
≥98% by NMR
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Documentation
Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem SDS
Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem Certificates of Analysis
Title
Lot Number
341251
References
Reference overview
Hormann, A., et al. 2001. Bioorg. Med. Chem.9, 917. Kirsch, G., et al. 2000. J. Nat. Prod.63, 825. Soni, R., et al. 2000. Biochem. Biophys. Res. Commun.275, 877.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
08-April-2011 RFH
Description
A cell-permeable red pigment, originally isolated from a species of marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 350 nM). Reported to inhibit Cdk6/cyclin D1 with much lower potency (IC50 = 3.4 µM). Exhibits little to no effect on the activities of several other Cdk's (IC50 >20 µM) and tyrosine kinases (IC50 >10 µM). Biological effects are attributed, in part, to its ability to intercalate into DNA. Also displays anti-microbial activity.
Form
Brown solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
114719-57-2
Chemical formula
C₁₈H₁₁ClN₂O
Structure formula
Purity
≥98% by NMR
Solubility
DMSO (10 mg/ml) or Methanol (1 mg/ml)
Storage
+2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Hormann, A., et al. 2001. Bioorg. Med. Chem.9, 917. Kirsch, G., et al. 2000. J. Nat. Prod.63, 825. Soni, R., et al. 2000. Biochem. Biophys. Res. Commun.275, 877.
