341251 Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem

A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 0.35 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CDK4/D1
341251
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₁ClN₂O 114719-57-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      341251-1MG
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          		 Alu drum 1 mg
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          Description
          OverviewA cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC50 = 0.35 µM). It inhibits Cdk6/D1 with much lower potency (IC50 = 3.4 µM) and has been shown not to affect the activities of several other Cdk’s (IC50 > 20 µM) and tyrosine kinases (IC50 > 10 µM). Part of its biological effects may also be attributed to its ability to intercalate into DNA. Has also been shown to display anti-microbial activity.
          Catalogue Number341251
          Brand Family Calbiochem®
          References
          ReferencesHormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
          Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
          Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.
          Product Information
          CAS number114719-57-2
          ATP CompetitiveY
          FormBrown solid
          Hill FormulaC₁₈H₁₁ClN₂O
          Chemical formulaC₁₈H₁₁ClN₂O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCDK4/D1
          Primary Target IC<sub>50</sub>0.35 µM against Cdk4/D1
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          341251

          References

          Reference overview
          Hormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
          Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
          Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2011 RFH
          DescriptionA cell-permeable red pigment, originally isolated from a species of marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 350 nM). Reported to inhibit Cdk6/cyclin D1 with much lower potency (IC50 = 3.4 µM). Exhibits little to no effect on the activities of several other Cdk's (IC50 >20 µM) and tyrosine kinases (IC50 >10 µM). Biological effects are attributed, in part, to its ability to intercalate into DNA. Also displays anti-microbial activity.
          FormBrown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number114719-57-2
          Chemical formulaC₁₈H₁₁ClN₂O
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO (10 mg/ml) or Methanol (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesHormann, A., et al. 2001. Bioorg. Med. Chem. 9, 917.
          Kirsch, G., et al. 2000. J. Nat. Prod. 63, 825.
          Soni, R., et al. 2000. Biochem. Biophys. Res. Commun. 275, 877.