344150 FPT Inhibitor I - Calbiochem

344150
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₉H₂₉NO₆P · 3Na

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344150-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewPotent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
      Catalogue Number344150
      Brand Family Calbiochem®
      Synonyms(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
      References
      ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
      Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₉H₂₉NO₆P · 3Na
      Chemical formulaC₁₉H₂₉NO₆P · 3Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFarnesyltransferase (Ftase)
      Primary Target IC<sub>50</sub>83 nM against Ftase
      Purity≥85% by NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      FPT Inhibitor I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FPT Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      344150

      References

      Reference overview
      Manne, V., et al. 1995. Drug Development Res. 34, 121.
      Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-December-2008 JSW
      Synonyms(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
      DescriptionA highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 83 nM). Inhibits geranylgeranyltransferase I (IC50 = 26 µM) and II (IC50 = 47 µM) at much higher concentrations.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉H₂₉NO₆P · 3Na
      Structure formulaStructure formula
      Purity≥85% by NMR
      SolubilityH₂O (≥10 mg/ml)
      Storage ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
      Toxicity Standard Handling
      ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
      Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors