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500670 FATP2 Inhibitor, CB-2 - Calbiochem

500670
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₁₁BrClNO₃S₂

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable thioxothiazolindine compound that reversibly inhibits FATP2-mediated long chain fatty acid uptake in Caco-2 and HepG2, but not non-FATP2-expressing 3T3-L1 adipocytes, cultures (IC50 = 3.99, 7.55, and 231.1 µM, respectively), while exhibiting much reduced potency toward cellular Acsl (acyl-CoA synthetase) activity (IC50 = 50 µM). Shown not to affect Caco-2 viability, membrane permeability, or glucose transport.
      Catalogue Number500670
      Brand Family Calbiochem®
      SynonymsFatty Acid Transport Protein 2 Inhibitor, (5E)-5-((3-bromo-4-hydroxy-5-methoxyphenyl)methylene)-3-(3-chlorophenyl)-2-thioxothiazolidin-4-one, CB2
      References
      ReferencesSandoval, A., et al. 2010. Biochem. Pharmacol. 79, 99.
      Product Information
      FormYellow solid
      Hill FormulaC₁₇H₁₁BrClNO₃S₂
      Chemical formulaC₁₇H₁₁BrClNO₃S₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>8 µ
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      FATP2 Inhibitor, CB-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Sandoval, A., et al. 2010. Biochem. Pharmacol. 79, 99.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-June-2013 JSW
      SynonymsFatty Acid Transport Protein 2 Inhibitor, (5E)-5-((3-bromo-4-hydroxy-5-methoxyphenyl)methylene)-3-(3-chlorophenyl)-2-thioxothiazolidin-4-one, CB2
      DescriptionA cell permeable thioxothiazolindine compound that reversibly inhibits FATP2- (fatty acid transport protein 2) mediated long chain fatty acid uptake in Caco-2 and HepG2, but not non-FATP2-expressing 3T3-L1 adipocytes, cultures (IC50 against C1-BODIPY-C12 = 3.99, 7.55, and 231.1 µM, respectively), exhibiting much reduced potency toward cellular Acsl (acyl-CoA synthetase) activity (IC50 = 50 µM using lysates from 1h inhibitor-treated Caco-2 cells). Shown not to affect Caco-2 viability (50 µM in MTT assay), membrane permeability (by trans-epithelial electrical resistance measurement; 50 µM), glucose transport (20 µM in 2-NBDG uptake assay).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₁BrClNO₃S₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSandoval, A., et al. 2010. Biochem. Pharmacol. 79, 99.