324833 EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem

The EGFR Inhibitor III, also referenced under CAS 733009-42-2, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide

Primary Target: EGFR
324833
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₀Cl₃FN₄O 733009-42-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      324833-5MG
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          		 Glass bottle 5 mg
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          Description
          OverviewA cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.
          Catalogue Number324833
          Brand Family Calbiochem®
          SynonymsN-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
          References
          ReferencesShushan, A., et al. 2007. Fertil. Steril. 87, 127.
          Product Information
          CAS number733009-42-2
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₆H₁₀Cl₃FN₄O
          Chemical formulaC₁₆H₁₀Cl₃FN₄O
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetEGFR
          Primary Target IC<sub>50</sub>0.7 µM and 1.1 µM suppressesing leiomyoma and myometrical cell proliferation, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          324833

          References

          Reference overview
          Shushan, A., et al. 2007. Fertil. Steril. 87, 127.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2011 RFH
          SynonymsN-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
          DescriptionA cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number733009-42-2
          Chemical formulaC₁₆H₁₀Cl₃FN₄O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml). Use fresh, anhydrous DMSO.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesShushan, A., et al. 2007. Fertil. Steril. 87, 127.