324833 Sigma-AldrichEGFR Inhibitor III - CAS 733009-42-2 - Calbiochem
The EGFR Inhibitor III, also referenced under CAS 733009-42-2, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The EGFR Inhibitor III, also referenced under CAS 733009-42-2, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
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Overview
Replacement Information |
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Key Specifications Table
CAS # | Empirical Formula |
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733009-42-2 | C₁₆H₁₀Cl₃FN₄O |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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324833-5MG |
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Glass bottle | 5 mg |
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Description | |
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Overview | A cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation. |
Catalogue Number | 324833 |
Brand Family | Calbiochem® |
Synonyms | N-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide |
References | |
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References | Shushan, A., et al. 2007. Fertil. Steril. 87, 127. |
Product Information | |
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CAS number | 733009-42-2 |
ATP Competitive | N |
Form | Yellow solid |
Hill Formula | C₁₆H₁₀Cl₃FN₄O |
Chemical formula | C₁₆H₁₀Cl₃FN₄O |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | EGFR |
Primary Target IC<sub>50</sub> | 0.7 µM and 1.1 µM suppressesing leiomyoma and myometrical cell proliferation, respectively |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Documentation
EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem SDS
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EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem Certificates of Analysis
Title | Lot Number |
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324833 |
References
Reference overview |
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Shushan, A., et al. 2007. Fertil. Steril. 87, 127. |