324674 EGFR Inhibitor - CAS 879127-07-8 - Calbiochem

324674
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₁H₁₈F₃N₅O 879127-07-8

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324674-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable 4,6-dianilinopyrimidine compound that acts as a potent, ATP-competitive, and highly selective inhibitor of EGFR and some EGFR mutants (IC50 = 21 nM, 63 nM, and 4 nM for EGFRwt, EGFRL858R and EGFRL861Q, respectively) vs. erbB4/Her4 (IC50 = 7.64 µM) and a panel of 55 other kinases. Shown to completely block EGF-induced EGFR autophosphorylation in U-2OS cells at 10 µM.
      Catalogue Number324674
      Brand Family Calbiochem®
      SynonymsCyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide
      References
      ReferencesZhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182
      Product Information
      CAS number879127-07-8
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₂₁H₁₈F₃N₅O
      Chemical formulaC₂₁H₁₈F₃N₅O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>21 nM, 63 nM, and 4 nM for EGFRwt, EGFRL858R and EGFRL861Q, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      EGFR Inhibitor - CAS 879127-07-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      EGFR Inhibitor - CAS 879127-07-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      324674

      References

      Reference overview
      Zhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-September-2007 JSW
      SynonymsCyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide
      DescriptionA cell-permeable 4,6-dianilinopyrimidine compound that acts as a potent, ATP-competitive, and highly selective inhibitor of EGFR and some EGFR mutants (IC50 = 21 nM, 63 nM, and 4 nM for EGFRwt, EGFRL858R and EGFRL861Q, respectively) vs. erbB4/Her4 (IC50 = 7.64 µM) and a panel of 55 other kinases. Shown to completely block EGF-induced EGFR autophosphorylation in U-2OS cells at 10 µM.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number879127-07-8
      Chemical formulaC₂₁H₁₈F₃N₅O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182