324412 Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid

324412
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₁₂ClN₃O₇

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      324412-10MG
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          		 Glass bottle 10 mg
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          Description
          OverviewA cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.
          Catalogue Number324412
          Brand Family Calbiochem®
          Synonyms4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid
          References
          ReferencesOdell, L.R., et al. 2010. J. Med. Chem. 53, 5267.
          Product Information
          FormLight yellow to beige solid
          Hill FormulaC₂₂H₁₂ClN₃O₇
          Chemical formulaC₂₂H₁₂ClN₃O₇
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Dynamin Inhibitor III, Phthaladyn-23 - Calbiochem Certificates of Analysis

          TitleLot Number
          324412

          References

          Reference overview
          Odell, L.R., et al. 2010. J. Med. Chem. 53, 5267.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2015 JSW
          Synonyms4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid
          DescriptionA cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.
          FormLight yellow to beige solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₁₂ClN₃O₇
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (7 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesOdell, L.R., et al. 2010. J. Med. Chem. 53, 5267.