533982 Dock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem

533982
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₉Cl₂NO₂S 54129-15-6

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      5.33982.0001
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          Glass bottle 50 mg
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          Description
          OverviewA cell-permeable, bioavailable, non-toxic benzenesulfonamide compound that directly blocks Dock5-mediated Rac activation (kcat/KM = 7.9 x 104 & 9.5 x 104 M-1s-1 for Rac1 & Rac2 by Dock5-DHR2, respectively) with selectivity over RhoA and Cdc42. At higher concentrations, affects Dock1 and Dock2 guanine nucleotide exchange factor activity. Shown to reversibly perturb podosome organization and inhibit osteoclastic bone degradation in a dose-dependent manner. Efficiently prevents both arthritis and metastasis-induced bone loss while preserving bone formation in several osteolytic disease mouse model (25 mg/kg, i.p. or i.v., 5 days a week for 4 weeks). Unlike alendronate (Cat. No. 126855), C21 does not impair bone formation.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number533982
          Brand Family Calbiochem®
          SynonymsN-(3,5-Dichlorophenyl)benzenesulfonamide
          References
          ReferencesVives, V., et al. 2015. Nat. Commun. 6, 6218.
          Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099.
          Product Information
          CAS number54129-15-6
          FormGrey powder
          Hill FormulaC₁₂H₉Cl₂NO₂S
          Chemical formulaC₁₂H₉Cl₂NO₂S
          ReversibleY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetDock5
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Dock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Vives, V., et al. 2015. Nat. Commun. 6, 6218.
          Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2017 JSW
          SynonymsN-(3,5-Dichlorophenyl)benzenesulfonamide
          DescriptionA cell-permeable, bioavailable, non-toxic benzenesulfonamide compound that directly blocks Dock5-mediated Rac activation (kcat/KM = 7.9 x 104 & 9.5 x 104 M-1s-1 for Rac1 & Rac2 by Dock5-DHR2, respectively) with selectivity over RhoA and Cdc42. At higher concentrations, affects Dock1 and Dock2 guanine nucleotide exchange factor activity. Shown to reversibly perturb podosome organization and inhibit osteoclastic bone degradation in a dose-dependent manner. Efficiently prevents both arthritis and metastasis-induced bone loss while preserving bone formation in several osteolytic disease mouse model (25 mg/kg, i.p. or i.v., 5 days a week for 4 weeks). Unlike alendronate (Cat. No. 126855), C21 does not impair bone formation.
          FormGrey powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number54129-15-6
          Chemical formulaC₁₂H₉Cl₂NO₂S
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesVives, V., et al. 2015. Nat. Commun. 6, 6218.
          Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099.