505757 Divin - Calbiochem

505757
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₂H₂₀N₄O₂

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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable, stable benzimidazolylpropanehydrazone that acts as a potent bacteriostatic agent and reduces the growth rate and transmembrane potential of bacterial cells without altering their membrane permeability. Blocks bacterial cell division by disturbing divisome assembly and causing dissociation of late division proteins from the divisome (MIC = 3, 5, 12.5, and 12.5 µM against V. cholerae, C. crescentus CB15N strain and JW5503 and YJE24 strains of E. coli, respectively). Also shown to reduce peptidoglycan remodeling and arrest the constriction in dividing cells. Does neither affect the tubulin homologue, FtsZ, nor interfere with replication, partitioning, and orientation of chromosomes. Exhibits low toxicity in mammalian cells.
      Catalogue Number505757
      Brand Family Calbiochem®
      SynonymsDIVision Inhibitor, Nʹ-((E)-(2-Hydroxynaphthalen-1-yl)methylidene)-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide, (E)-Nʹ-((2-Hydroxynaphthalen-1-yl)methylene)-3-(2-methyl-1H-benzo[d]imidazol-1-yl)propanehydrazide
      References
      ReferencesEun, Y.J., et al. 2013. J. Am. Chem. Soc. 135, 9768.
      Product Information
      FormYellow powder
      Hill FormulaC₂₂H₂₀N₄O₂
      Chemical formulaC₂₂H₂₀N₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targetbacteria
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Divin - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Eun, Y.J., et al. 2013. J. Am. Chem. Soc. 135, 9768.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      SynonymsDIVision Inhibitor, Nʹ-((E)-(2-Hydroxynaphthalen-1-yl)methylidene)-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide, (E)-Nʹ-((2-Hydroxynaphthalen-1-yl)methylene)-3-(2-methyl-1H-benzo[d]imidazol-1-yl)propanehydrazide
      DescriptionA cell-permeable, stable benzimidazolylpropanehydrazone that acts as a potent bacteriostatic agent and reduces the growth rate and transmembrane potential of bacterial cells without altering their membrane permeability. Blocks bacterial cell division by disturbing divisome assembly and causing dissociation of late division proteins from the divisome (MIC = 3, 5, 12.5, and 12.5 µM against V. cholerae, C. crescentus CB15N strain and JW5503 and YJE24 strains of E. coli, respectively). Also shown to reduce peptidoglycan remodeling and arrest the constriction in dividing cells. Does neither affect the tubulin homologue, FtsZ, nor interfere with replication, partitioning, and orientation of chromosomes. Exhibits low toxicity in mammalian cells.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₂₀N₄O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesEun, Y.J., et al. 2013. J. Am. Chem. Soc. 135, 9768.