662141 DUB Inhibitor V, PR-619 - Calbiochem

662141
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₇H₅N₅S₂

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662141-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 (Cat. No. 662142) are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 µM; 0.5 to 20 h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains.
      Catalogue Number662141
      Brand Family Calbiochem®
      SynonymsPR619, UCH-L1 Inhibitor IV, UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I, 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine
      References
      ReferencesAltun, M., et al. 2011. Chem. Biol. 18, 1401.
      Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165.
      Product Information
      FormBeige solid
      Hill FormulaC₇H₅N₅S₂
      Chemical formulaC₇H₅N₅S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDUB Inhibitor V, PR-619, CAS 21645-32-1, is a cell-permeable, broad-spectrum DUB inhibitor whose (C50 = 5-20 M).
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      DUB Inhibitor V, PR-619 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      DUB Inhibitor V, PR-619 - Calbiochem Certificates of Analysis

      TitleLot Number
      662141

      References

      Reference overview
      Altun, M., et al. 2011. Chem. Biol. 18, 1401.
      Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-November-2012 JSW
      SynonymsPR619, UCH-L1 Inhibitor IV, UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I, 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine
      DescriptionA cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 (Cat. No. 662142) are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 µM; 0.5 to 20 h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₇H₅N₅S₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAltun, M., et al. 2011. Chem. Biol. 18, 1401.
      Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165.