376650 D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem

376650
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₄H₄₇NO₃ 124753-97-5

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376650-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewBiologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
      Catalogue Number376650
      Brand Family Calbiochem®
      SynonymsC₆ Ceramide
      References
      ReferencesJayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
      Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
      Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
      Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
      Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
      Product Information
      CAS number124753-97-5
      ATP CompetitiveN
      FormWhite waxy solid
      Hill FormulaC₂₄H₄₇NO₃
      Chemical formulaC₂₄H₄₇NO₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMAP kinase, protein phosphatase 2A (PP2A)
      Primary Target IC<sub>50</sub>Effective concentration: 10 nM in activating protein phosphatase 2A (PP2A)
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      376650

      References

      Reference overview
      Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
      Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
      Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
      Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
      Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.

      Brochure

      Title
      Bioactive Lipids Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-September-2019 JSW
      SynonymsC₆ Ceramide
      DescriptionBiologically active, cell-permeable, nonphysiological ceramide analog. Stimulates cytosolic serine/threonine protein phosphatase in T9 cells and induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. Induces a dramatic arrest in the Go/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis in Molt-4 leukemia cells.
      FormWhite waxy solid
      CAS number124753-97-5
      Chemical formulaC₂₄H₄₇NO₃
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO or Ethanol (25 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Irritant
      ReferencesJayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
      Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
      Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
      Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
      Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.