250401 Cytoplasmic Dynein Inhibitor, Ciliobrevin D - Calbiochem

250401
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₈Cl₃N₃O₂

Pricing & Availability

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250401-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10 to 40 µM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling.
      Catalogue Number250401
      Brand Family Calbiochem®
      Synonyms2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor
      References
      ReferencesFirestone, A., et al. 2012. Nature.
      484, 125.
      Product Information
      FormOrange powder
      Hill FormulaC₁₇H₈Cl₃N₃O₂
      Chemical formulaC₁₇H₈Cl₃N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cytoplasmic Dynein Inhibitor, Ciliobrevin D - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cytoplasmic Dynein Inhibitor, Ciliobrevin D - Calbiochem Certificates of Analysis

      TitleLot Number
      250401

      References

      Reference overview
      Firestone, A., et al. 2012. Nature.
      484, 125.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-October-2012 JSW
      Synonyms2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor
      DescriptionA cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10 to 40 µM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling.
      FormOrange powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₈Cl₃N₃O₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (2.5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFirestone, A., et al. 2012. Nature.
      484, 125.