Product Information
Applications
ApplicationCdc42/Rac1 GTPase Inhibitor, ML141, CAS 71203-35-5, is a cell-permeable, allosteric, potent, selective, reversible, non-competitive inhibitor of Cdc42 GTPases.
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem Certificates of Analysis

TitleLot Number
217708

References

Reference overview
Hong, L., et al. 2012. J. Biol. Chem. in press.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-February-2013 JSW
SynonymsCDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II, CID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334
DescriptionA cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (> 95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM.
FormYellow-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number71203-35-5
Chemical formulaC₂₂H₂₁N₃O₃S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHong, L., et al. 2012. J. Biol. Chem. in press.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > GTPase Inhibitors