218728 Caspase-9 Inhibitor III - CAS 403848-57-7 - Calbiochem

218728
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₂₄H₃₅ClN₆O₉ 403848-57-7

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218728-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).
      Catalogue Number218728
      Brand Family Calbiochem®
      SynonymsAc-LEHD-CMK
      References
      ReferencesMocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197.
      Product Information
      CAS number403848-57-7
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₄H₃₅ClN₆O₉
      Chemical formulaC₂₄H₃₅ClN₆O₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-9
      Primary Target IC<sub>50</sub>70 nM against caspase-9
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Leu-Glu-His-Asp-CMK
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase-9 Inhibitor III - CAS 403848-57-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-9 Inhibitor III - CAS 403848-57-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      218728

      References

      Reference overview
      Mocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsAc-LEHD-CMK
      DescriptionA potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      CAS number403848-57-7
      Chemical formulaC₂₄H₃₅ClN₆O₉
      Peptide SequenceAc-Leu-Glu-His-Asp-CMK
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or (1 mg/ml) H₂O
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197.