218833 Caspase-6 Inhibitor XII, pep419 - Calbiochem

218833
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₉₉H₁₆₂N₃₀O₂₉S

Pricing & Availability

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218833-5MG
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      Glass bottle 5 mg
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      Description
      OverviewAn 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
      Catalogue Number218833
      Brand Family Calbiochem®
      SynonymsCaspase inhibitor, pep419
      References
      ReferencesStanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.
      Product Information
      FormWhite powder
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₉₉H₁₆₂N₃₀O₂₉S
      Chemical formulaC₉₉H₁₆₂N₃₀O₂₉S
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceAc-TEKEKGRLHCVEWTILER-NH2
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase-6 Inhibitor XII, pep419 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-6 Inhibitor XII, pep419 - Calbiochem Certificates of Analysis

      TitleLot Number
      218833

      References

      Reference overview
      Stanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-June-2013 JSW
      SynonymsCaspase inhibitor, pep419
      DescriptionAn 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
      FormWhite powder
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₉₉H₁₆₂N₃₀O₂₉S
      Peptide SequenceAc-TEKEKGRLHCVEWTILER-NH2
      Purity≥95% by HPLC
      SolubilityH₂O (100 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesStanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.